Journal: Communications Biology

Article Title: Single-nucleus multi-omics analysis of mouse small-intestinal Lgr5+ cell populations reveals Foxa3-induced Paneth cell-lineage differentiation

doi: 10.1038/s42003-026-09736-2

Figure Lengend Snippet: a Schematic of Lgr5+ cell sorting and multi-omics sequencing. Feature plots showing the expression of Lgr5. b UMAPs showing identified cell types in mouse small intestine epithelial cells using combined gene (mRNA) and chromatin accessibility (ATAC) information. c Dot plot showing the expression levels and the percentages of gene expression of the canonical genes in each distinct cell type. d Trajectory and pseudotime analysis of the small intestinal crypt cells. The trajectories indicate that ISC differentiates in both directions, and the cells are colored by pseudotime. e CytoTrace2 prediction results for the differentiation potential of small intestinal epithelial cells.

Article Snippet: These Lgr5+ stem cells were processed and sequenced using single-nucleus multi-omics (10x Genomics Multiomics), obtaining paired gene expression (messenger RNA) and chromatin accessibility (ATAC) information for the same cell (Fig. , Supplementary Fig. ).

Techniques: FACS, Biomarker Discovery, Sequencing, Expressing, Gene Expression

Journal: Journal of Biomedical Optics

Article Title: Color-filter-array-based multispectral photoplethysmography optical sensor and its motion artifact correction algorithm

doi: 10.1117/1.JBO.31.3.037001

Figure Lengend Snippet: (a) Synchronous multi-channel PPG sensor module. (b) Multi-wavelength PPG signals measured at an LED-PD distance of 2 mm using the wrist-worn reflective PPG sensor with color filters.

Article Snippet: Based on the aforementioned simulation results, a compact multi-channel PPG synchronous acquisition sensor module was designed using Altium Designer and fabricated.

Techniques:

Journal: Journal of Biomedical Optics

Article Title: Color-filter-array-based multispectral photoplethysmography optical sensor and its motion artifact correction algorithm

doi: 10.1117/1.JBO.31.3.037001

Figure Lengend Snippet: Measured spectral transmittance curves of the multi-channel filters integrated into the sensor. (a) 660-nm red-light channel filter. (b) 940-nm infrared-light channel filter. Data provided by the manufacturer.

Article Snippet: Based on the aforementioned simulation results, a compact multi-channel PPG synchronous acquisition sensor module was designed using Altium Designer and fabricated.

Techniques: